Janine L. Kwapis Y. Alaghband +7 authors M. Wood. Biology, Psychology. Neuropsychopharmacology. 2019; TLDR. It is demonstrated that hippocampal memory updating is impaired with aging and established that the OUL paradigm is an effective, sensitive method of assessing memory updating in rodents. Expand. 19.Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Metrics and citations MetricsJarome, T. J., & Kwapis, J. L. (2021). Special issue “molecular mechanisms of memory formation and modification”. International journal of molecular sciences, 22 ...Figure 3. TetTag and TRAP systems allow neurons active during specific time windows to be persistently tagged. (A) Tet-tag system. Two transgenes control tagging of active neurons: 1) tTA under the control of the activity-dependent cFos promoter and a TetO promoter that drives both the gene of interest (e.g. a reporter gene) and the dox-insensitive tTA* mutant that drives persistent expression ...May 26, 2016 · Graham D. L. et al.. Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat. Neurosci. 10, 1029–1037 (2007). [Google Scholar] Graham D. L. et al.. Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol. Psychiatry 65, 696–701 (2009). Janine L Kwapis; Both the circadian clock and sex hormone signaling can strongly influence brain function, yet little is known about how these 2 powerful modulatory systems might interact during ...Timothy J. Jarome, Janine L. Kwapis, Wendy L. Ruenzel and Fred J. Helmstetter* Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and memory formation through their regulation of protein synthesis. Consistent with this, numerous ...In the laboratory, memory is typically studied as a de novo experience, in which a naïve animal is exposed to a discrete learning event that is markedly different from its past experiences.The past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals.Histone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation in response to a learning event.Janine Kwapis Assistant Professor, Biology h-index 1482 Citations 24 h-index 2009 2023 Research activity per year Overview Fingerprint Network Grants & Projects (4) Research output (43) Similar Profiles (1) If you made any changes in Pure these will be visible here soon. Personal profileEurope PMC is an archive of life sciences journal literature.Propensity to relapse following long-periods of abstinence is a key feature of substance use disorder. Drugs of abuse, such as cocaine, cause long-term changes in the neural circuitry regulating reward, motivation, and memory processes through dysregulation of various molecular mechanisms, including epigenetic regulation of activity-dependent gene expression.Janine L. Kwapis ValeriaLallai MichaelS. Landy FionaE. N. LeBeau JaeK. Lee Christian H. Lemon JannaD. Lendner TylorR. Lewis Ya Dong Li Kyle P.Lillis Taosheng Liu DanielA.Llano HanbingLu HeikoJ. Luhmann Bryan W. Luikart Carl R.Lupica GyorgyLur KevinLuxem DingbangMa AngelaM. Mabb GuidoMaiello Joost X. Maier Elias Manjarrez MassimoMantegazza ...Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.Janine L. Kwapis1, Timothy J. Jarome2, ... (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014) and have hypothesized that trace memory may be stored in a distributed cortical network that includes prelimbic and retrosplenial cortices (Kwapis, Jarome, & Helmstetter, 2015). Whether the RSC participates in acquir-Undergraduate Research and Fellowships Mentoring Office. 321 Boucke Building. University Park, PA 16802. 814-863-8199 | [email protected] past decade has produced an explosion in the number and variety of genetic tools available to neuroscientists, resulting in an unprecedented ability to precisely manipulate the genome and epigenome in behaving animals.Curriculum Vitae Janine Kwapis 3 7. López AJ, Hemstedt TJ, Jia Y, Hwang PH, Campbell RR, Kwapis JL, White AO, Chitnis O, Scarfone VM, Matheos DP, Lynch G, Wood MA. (2019). Epigenetic regulation of immediate-early gene Nr4a2/Nurr1 in the medial habenula during reinstatement of cocaine-associated behavior. Neuropharmacology, 153: 13-19. PMID ...Timothy J. Jarome, Craig T. Werner, # Janine L. Kwapis, # and Fred J. Helmstetter * Efthimios M. C. Skoulakis, Editor. Author information Article ... Mouledous L, Frances B, et al. Protein degradation, as with protein synthesis, is required not only during long-term spatial memory consolidation but also reconsolidation. Eur J Neurosci. ...Janine L. Kwapis. Department of Neurobiology and Behavior, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. UC Irvine Center for Addiction Neuroscience, Ayala School of Biological Sciences, University of California, Irvine, CA, USA. Search for more papers by this author.Special Issue "Molecular Mechanisms of Memory Formation and Modification". A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology". Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 33327.Janine L. Kwapis Timothy J Jarome M. E. Lonergan F. Helmstetter Biology, Psychology Behavioral neuroscience 2009 TLDR The results indicate that PKMzeta inhibition in the amygdala, but not in the hippocampus, can disrupt fear memory, which suggests that ...He's Just Not That Into You is a 2009 American romantic comedy-drama film directed by Ken Kwapis, based on Greg Behrendt and Liz Tuccillo's 2004 self-help ...Author links open overlay panel Sydney Trask a, Nicole C. Ferrara b, Aaron M. Jasnow c, Janine L. Kwapis d. Show more. Add to Mendeley. Share. ... J.L. Kwapis et al. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiol. Learn. Mem. (2015)Janine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter Input from the ...Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined.He's Just Not That Into You is a 2009 American romantic comedy-drama film directed by Ken Kwapis, based on Greg Behrendt and Liz Tuccillo's 2004 self-help ...The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning Janine L. Kwapis1, Timothy J. Jarome2, Jonathan L. Lee, Fred J. Helmstetter Department of Psychology, University of Wisconsin–Milwaukee, 2441 E. HartfordJanine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined.Protein Kinase Mzeta. PKMζ is an atypical isoform of protein kinase C (PKC) that is believed to actively maintain those cellular changes that occur during memory formation in order to preserve the memory engram over time. In vitro work has demonstrated that PKMζ is both necessary and sufficient to maintain established long-term potentiation ...Nicole C Ferrara 1 2 , Janine L Kwapis 3 , Sydney Trask 4 5 Affiliations 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States. 2 Center for Neurobiology of Stress Resilience and …Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However, accumulated evidence indicates a functional dissociation within the hippocampus such that contextual learning is primarily associated with ...Alzheimer's Disease affects 5.4 million Americans [1] and by 2030, approximately 13.8 million people 65 or older are projected to have the disease [2]. Even more individuals will experience normal age...Peer-reviewed scientific journal publishing basic neuroscience research in the areas of neuronal plasticity, learning and memoryYasaman Alaghband 1 2 3 , Enikö Kramár 1 3 , Janine L Kwapis 1 4 3 , Earnest S Kim 5 , Thekla J Hemstedt 1 3 , Alberto J López 1 2 3 , André O White 1 2 3 , Amni Al-Kachak 1 3 , Osasumwen V Aimiuwu 1 3 , Kasuni K Bodinayake 1 3 , Nicole C Oparaugo 1 3 , Joseph Han 1 3 , K Matthew Lattal 5 , Marcelo A Wood 6 2 4 3Author(s): Kwapis, Janine L; Alaghband, Yasaman; Kramár, Enikö A; López, Alberto J; Vogel Ciernia, Annie; White, André O; Shu, Guanhua; Rhee, Diane; ...Janine L. Kwapis, Timothy J. Jarome, Jonathan L. Lee, Marieke R. Gilmartin, Fred J. Helmstetter. Pages 41-54 View PDF. Article preview. select article Fear extinction can be made state-dependent on peripheral epinephrine: Role of norepinephrine in the nucleus tractus solitarius.Janine L. Kwapis The University of Wisconsin-Milwaukee, 2013 Under the Supervision of Professor Fred J. Helmstetter A wealth of research has outlined the neural circuits responsible for the consolidation, reconsolidation, and extinction of standard "delay" fear conditioning, in which awareness is not required for learning.Int. J. Mol. Sci. 2021, 22, 4113 2 of 3 colleagues reviewed the epigenetic factors involved in memory consolidation in young, healthy adults and how these mechanisms are altered with age [5].Contributors: Janine L. Kwapis; Timothy J. Jarome; Marieke R. Gilmartin; Fred J. Helmstetter Show more detail. Source: Marieke Gilmartin via Crossref Metadata …Finally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ...Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However, accumulated evidence indicates a functional dissociation within the hippocampus such that contextual learning is primarily associated with ...Brief Communication The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation Timothy J. Jarome,1 Janine L. Kwapis,1 Jada J. Hallengren,2 Scott M. Wilson,2 and Fred J. Helmstetter1,3 1Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA; 2Department of Neurobiology, University of Alabama, Birmingham, Alabama 35294, USAThe circadian system plays an important role in aligning biological processes with the external time of day. A range of physiological functions are governed by the circadian cycle, including memory processes, yet little is understood about how the clock interfaces with memory at a molecular level. The molecular circadian clock consists of four ...Abstract In the laboratory, memory is typically studied as a de novo experience, in which a naïve animal is exposed to a discrete learning event that is markedly different from its past experiences...Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioningContext and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala Janine L Kwapis1,2, Yasaman Alaghband1, Alberto J López1, André O White3, Rianne R Campbell1, Richard T Dang1, Diane Rhee1, Ashley V Tran1, Allison E Carl1, Dina P Matheos1 and Marcelo A Wood*,1,2 1Department of Neurobiology and Behavior, Center for the Neurobiology of ...Janine L. Kwapis, 1, 2, 3 Yasaman Alaghband, 1, 2 Enikö A. Kramár, 1, 2 Alberto J. López, 1, 2 Annie Vogel Ciernia, 4 André O. White, 5 Guanhua Shu, 1, 2 Diane ...Previous work from our lab (Kwapis et al., 2011, Kwapis et al., 2014, Kwapis et al., 2015) has demonstrated that a 6-trial trace fear conditioning protocol with a variable intertrial interval (ITI) of 240 ± 20 s produces approximately the same level of freezing as 4 trials of delay fear conditioning with a shorter ITI of 110 ± 20 s.PDF | On Mar 26, 2012, Marieke R Gilmartin and others published Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or ...Assistant Professor of Biology Department of Biology jlk855 Janine Kwapis Biography Education B.A., Psychology, Alma College M.S., Behavioral Neuroscience, University of Wisconsin-Milwaukee Ph.D., Behavioral Neuroscience, University of Wisconsin-Milwaukee Postdoc Training University of California, Irvine Research Interests Sep 22, 2011 · All animals were handled for several days prior to surgery. Rats that underwent surgery were implanted with bilateral cannulas aimed at the amygdala [anteroposterior [AP], −2.8; Lateral [L], +/− 5.0; Ventral [V], −7.2]. Coordinates were chosen based on a rat brain atlas . Before surgery, each rat was anesthetized with an intraperitoneal ... AU - Kwapis, Janine L. N1 - Funding Information: Funding: This research was funded by NIH grants K99/R00AG056586 (J.L.K.) and R21AG068444 (J.L.K.), Whitehall Foundation Grant #2020-05-06 (J.L.K.), startup funds from the Eberly College of Science and Department of Biology at Pennsylvania State University (J.L.K.) and the National Institute on ...Author links open overlay panel Janine L. Kwapis, Marcelo A. Wood. Show more. Add to Mendeley. Share. ... DA031989) to M.A. Wood, and National Institute on Aging (NIA) T32 grant AG000096-31 to J.L.K. Glossary. Consolidation the process of converting temporary short-term memory (lasting only a few hours) ...The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning Janine L. Kwapis1, Timothy J. Jarome2, Jonathan L. Lee, Fred J. Helmstetter Department of Psychology, University of Wisconsin–Milwaukee, 2441 E. HartfordAuthor links open overlay panel Sydney Trask a, Nicole C. Ferrara b, Aaron M. Jasnow c, Janine L. Kwapis d. Show more. Add to Mendeley. Share. ... J.L. Kwapis et al. The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiol. Learn. Mem. (2015)Following fear conditioning, behavior can be reduced by giving many CS-alone presentations in a process known as extinction or by presenting a few CS-alone presentations and interfering with subsequent memory reconsolidation.The circadian system influences many different biological processes, including memory performance. While the suprachiasmatic nucleus (SCN) functions as the brain's central pacemaker, satellite clocks have also been identified in other brain regions, such as the memory-relevant dorsal hippocampus. Although it is unclear how these satellite clocks contribute to brain function, one possibility ...Apr 28, 2018 · The results indicate that spatial memory reconsolidation depends on the functionality of L-VDCC in dorsal CA1, that maintenance of subsequent reconsolidated memory trace depends on CaMKII, and suggest that the role played by both L-vdCC and CaMK II is to promote the retrieval-dependent, synaptically localized enhancement of protein synthesis necessary to counteract a retrieval- dependent ... Jun 6, 2019 · This work was supported by National Institutes of Health Grants MH101491, AG051807, and AG050787 to M.A.W., the National Institute on Aging Grants F32 AG052303 and K99 AG056596 to J.L.K., and in part by the Intramural Research Program of the National Institute on Aging. We thank Dr. Timothy Bredy for his help developing the HA-Nr4a1 virus. Janine L. Kwapis: Conceptualization, Methodology, Writing – original draft, Writing – review & editing, Supervision, Project administration, Funding acquisition. Declaration of Competing Interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the …Hervera A, Zhou L, Palmisano I, et al. (2019) PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure. The Embo Journal Kwapis JL, Alaghband Y, López AJ, et al. ( 2019 ) HDAC3-mediated repression of the family contributes to age-related impairments in long-term memory.Janine L. Kwapis, Timothy J. Jarome, Janet C. Schiff, and Fred J. Helmstetter1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA Memory for delay fear conditioning requires the synthesis of new mRNA and protein in the basolateral amygdala. It isJarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learn Mem 19: 300-306. [PMC free article] [Google Scholar] Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ (2011).Jul 19, 2023 · Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Metrics and citations Metrics Kwapis, Janine Lynn: F31 Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). The Role of Protein Kinase Mzeta in Hippocampal-Dependent Memory Maintenance.Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Janine L Kwapis; Timothy J Jarome; Nicole C Ferrara; Fred J Helmstetter; Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work ...Janine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter. Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter.Janine Kwapis, assistant professor of biology at Penn State, appointed as the Paul Berg Early Career Professor in the Biological SciencesJanine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp, Marcelo A. WoodJanine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter. Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter.1. To whom all correspondence should be addressed: Janine L. Kwapis, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA; e-mail: [email protected]. Connecting the Dots: Potential Interactions Between Sex Hormones and the Circadian System During Memory ConsolidationAU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6. Y1 - 2014/6. N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during ...Kwapis JL, Alaghband Y, Kramar EA, Lopez AJ, Vogel Ciernia A, White AO, Shu G, Rhee D, Michael CM, Montellier E, Liu Y, Magnan CN, Chen S, Sassone-Corsi P, …Histone deacetylase 3 (HDAC3) is the most highly expressed Class I HDAC in the brain, and this specific HDAC is a powerful negative regulator of learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge et al., 2013).Janine L. Kwapis ValeriaLallai MichaelS. Landy FionaE. N. LeBeau JaeK. Lee Christian H. Lemon JannaD. Lendner TylorR. Lewis Ya Dong Li Kyle P.Lillis Taosheng Liu DanielA.Llano HanbingLu HeikoJ. Luhmann Bryan W. Luikart Carl R.Lupica GyorgyLur KevinLuxem DingbangMa AngelaM. Mabb GuidoMaiello Joost X. Maier Elias Manjarrez MassimoMantegazza ...1 Title Page Article Type: Regular Manuscript Title : CREST in the nucleus accumbens core regulates cocaine conditioned place preference, cocaine-seeking behavior, andJanine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...Injection of corticosterone (CORT) in the dorsal hippocampus (DH) can mimic post-traumatic stress disorder (PTSD)—related memory in mice: both maladaptive hypermnesia for a salient but irrelevant simple cue and amnesia for the traumatic context. However, accumulated evidence indicates a functional dissociation within the hippocampus such that contextual learning is primarily associated with ...Author links open overlay panel Yasaman Alaghband a b c, Janine L. Kwapis a b d, Alberto J. López a b c, André O. White a b c 1, Osasumwen V. Aimiuwu a b c 2, Amni Al-Kachak a b c 3, Kasuni K. Bodinayake a b c, Nicole C. Oparaugo a b c, Richard Dang aJanine l. kwapis
Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA ... (NIMH) grants R01MH069558 to F.J.H. and NIMH grant F31MH090685 to J.L.K. We thank Marieke R. Gilmartin and Jonathan L. Lee for technical assistance. Previous Section Next Section ...Janine L. Kwapis , Contributed equally to this work with: Craig T. Werner, Janine L. Kwapis Affiliation Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin, United States of America ⨯ . Fred J. Helmstetter * E-mail: [email protected] regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.Janine L. Kwapis, Yasaman Alaghband, Ashley A. Keiser, Tri N. Dong, Christina M. Michael, Diane Rhee, Guanhua Shu, Richard T. Dang, Dina P. Matheos, Marcelo A. WoodWe have previously shown that trace fear extinction requires the RSC (Kwapis, Jarome, Lee, Gilmartin, & Helmstetter, 2014) and have hypothesized that trace …This work was supported by the National Institutes of Health (grants R00AG056596 and R21AG068444) awarded to J.L.K.; the Whitehall Foundation (grant 2020-05-06 to J.L.K.); and was conducted while Janine Kwapis was a Glenn Foundation for Medical Research and AFAR Grant for Junior Faculty awardee.Timothy J. Jarome, Janine L. Kwapis, Jada J. Hallengren, et al. long-term memory formation The ubiquitin-specific protease 14 (USP14) is a critical regulator ofOct 12, 2022 · View ORCID Profile Lauren Bellfy, View ORCID Profile Chad W. Smies, Alicia R. Bernhardt, View ORCID Profile Kasuni K. Bodinayake, Aswathy Sebastian, Emily M. Stuart, Destiny S. Wright, Chen-Yu Lo, Shoko Murakami, View ORCID Profile Hannah M. Boyd, Megan J. von Abo, View ORCID Profile Istvan Albert, View ORCID Profile Janine L. Kwapis Janine L. Kwapis, Ph.D., Department of Biology, Penn State University ... it is unknown whether these biological processes share a common mechanism that is altered with age. Dr. Kwapis will present evidence that epigenetic regulation of the circadian gene Period1 (Per1) in the dorsal hippocampus is critical for memory formation and contributes ...Janine L. Kwapis, Ph.D. 201 Qureshey Research Lab Irvine, CA 92697 Phone: (949) 824-2356 E-Mail: [email protected] Current Position Postdoctoral Fellow, University of …Janine L. Kwapis, Yasaman Alaghband, Alberto J. López, Jeffrey M. Long, Xiang Li, Guanhua Shu, Kasuni K. Bodinayake, Dina P. Matheos, Peter R. Rapp and ...Janine L. Kwapis: Conceptualization, Methodology, Writing – original draft, Writing – review & editing, Supervision, Project administration, Funding acquisition. Declaration of Competing Interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the …Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA Corresponding author: fjh{at}uwm.edu Abstract The extinction of …Janine L. Kwapis, Timothy J. Jarome, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 14 Scopus citations. Overview; Fingerprint; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. Whether this ...Janine L Kwapis, Tim J Jarome, Nicole C Ferrara, & Fred J Helmstetter. Context memory formation requires activity-dependent protein degradation in the hippocampus. Patrick K Cullen, Nicole C Ferrara, Shane E Pullins, & Fred J Helmstetter.Alaghband Y, Kwapis JL, López AJ, White AO, Aimiuwu OV, Al-Kachak A, Bodinayake KK, Oparaugo NC, Dang R, Astarabadi M, Matheos DP, Wood MA (2017) Distinct roles for the deacetylase domain of HDAC3 in the hippocampus and medial prefrontal cortex in the formation and extinction of memory.Kwapis, Janine L Alaghband, Yasaman López, Alberto J et al. Publication Date 2017-05-01 DOI 10.1038/npp.2016.274 Peer reviewed eScholarship.org Powered by the California Digital Library University of California. Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the …Janine Kwapis Page 2 • First Place Award for Oral Presentation, UCI ReMIND Emerging Scientists Symposium, UC Irvine 2015 • NIH T32 Institutional Training Grant Recipient, UCI MIND 2014-2016 • NIH F31 Predoctoral Ruth L. Kirschstein National Research Service Award (NRSA) - 3 year fellowship 2011-2013Europe PMC is an archive of life sciences journal literature.Janine L. Kwapis, Ph.D. Assistant Professor Paul Berg Early Career Professor in the Biological Sciences Department of Biology, Pennsylvania State University Office: 516 Mueller Lab ½ Lab: 508 Mueller Lab University Park, PA 16802 Phone: 814-863-0859 Email: [email protected] Website: www.kwapislab.com CURRENT POSITION Pennsylvania State University Janine L. Kwapis, Ph.D., Department of Biology, Penn State University Public Neuroscience Seminar; Wednesday, December 4th, 2019; 11:00 am – 12:00pm; Fralin Auditorium; Aging is accompanied by impairments in both long-term memory and circadian rhythmicity.Janine L. Kwapis, Timothy J. Jarome, Nicole C. Ferrara, Fred J. Helmstetter. Biology; Research output: Contribution to journal › Article › peer-review. 16 Scopus citations. Overview; Fingerprint; Abstract. Established memories undergo a period of vulnerability following retrieval, a process termed 'reconsolidation.' Recent work has shown ...AU - Kwapis, Janine L. AU - Helmstetter, Fred J. PY - 2014/6. Y1 - 2014/6. N2 - Work on the long-term stability of memory has identified a potentially critical role for protein kinase Mzeta (PKMζ) in maintaining established memory. PKMζ, an autonomously active isoform of PKC, is hypothesized to sustain those changes that occurred during ...Lauren Bellfy 1 2 , Chad W Smies 1 , Alicia R Bernhardt 1 , Kasuni K Bodinayake 1 , Aswathy Sebastian 2 , Emily M Stuart 1 , Destiny S Wright 1 , Chen-Yu Lo 1 , Shoko Murakami 1 , Hannah M Boyd 1 2 , Megan J von Abo 1 , Istvan Albert 2 3 , Janine L Kwapis 4 5 Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process.Janine L. Kwapis, Timothy J. Jarome and Fred J. Helmstetter; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA; Corresponding author: fjh{at}uwm.edu; Abstract. The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined. ...Memory is not a stable record of experience, but instead is an ongoing process that allows existing memories to be modified with new information through a reconsolidation-dependent updating process.Check out Similar Professors in the Biological Sciences Department. 5.00 David Geiser. 5.00 James Howell. 5.00 Jan Van Riggelen. 0 Student Ratings. Janine Kwapis is a professor in the Biological Sciences department at Penn State University - see what their students are saying about them or leave a rating yourself.Quantitative real-time RT-PCR was performed to measure CREST expression following one-trial cocaine conditioning as previously described (López et al., 2016; White et al., 2016; Alaghband et al., 2017; Kwapis et al., 2017). Punches (0.5 mm) in the NAc were collected from 500 μm slices. All tissue was stored at −80°C until processing.Europe PMC is an archive of life sciences journal literature. https://orcid.orgThe major difference is that Parsons and Davis (2011a) infused a Indeed, preliminary research from the Sacktor laboratory has found volume of 0.5 l per hemisphere into the amygdala, as compared compensatory increases in PKC/ phosphorylation when PKM is J.L. Kwapis, F.J. Helmstetter / Brain Research Bulletin 105 (2014) 36-45 41select article Elevated fear responses to threatening cues in rats with early life stress is associated with greater excitability and loss of gamma oscillations in ventral-medial prefrontal cortexFinally, Bellfy and Kwapis review the evidence that the reconsolidation process may allow existing memories to update in response to new, relevant information . In their review, the authors outline the major behavioral paradigms used to study reconsolidation and describe the different molecular mechanisms across the brain that support this ...Timothy J Jarome, Janine L. Kwapis, Jada J. Hallengren, Scott M Wilson, F. Helmstetter. Biology. Learning & memory. 2013; TLDR. It is found that infusion of a USP14 inhibitor into the amygdala impaired long-term memory for a fear conditioning task, suggesting that USP 14 is a critical regulator of long- term memory formation in the amygdala.Bellfy L, Kwapis JL. (2020) Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. International Journal of Molecular Sciences. 21: Wright DS, Bodinayake KK, Kwapis JL. (2020) Investigating Memory Updating in Mice Using the Objects in Updated Locations Task. Current Protocols in Neuroscience. 91: e87: Navabpour S, Kwapis JL, Jarome TJ.CaMKII and Protein Kinase A (PKA) are thought to be critical for synaptic plasticity and memory formation through their regulation of protein synthesis. Consistent with this, numerous studies have reported that CaMKII, PKA and protein synthesis are critical for long-term memory formation. Recently, …Learning, memory, fear conditioning, trace conditioning, optogenetics, electrophysiology, single-uniLauren Bellfy, Aswathy Sebastian, Hannah M. Boyd, Istvan Albert & Janine L. Kwapis. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802 ...Search life-sciences literature (42,985,652 articles, preprints and more) SearchHow to say Janine L Kwapis in English? Pronunciation of Janine L Kwapis with and more for Janine L Kwapis.The latest tweets from @J9KwapisHistone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in acetylation in response to a learning event.Christopher W. Butler, Ashley A. Keiser, Janine L. Kwapis, Nicole C. Berchtold, Vanessa L. Wall, Marcelo A. Wood, Carl W. Cotman; Exercise opens a temporal window for enhanced cognitive improvement from subsequent physical activity; Learn Mem. 2019 Dec; 26(12): 485-492. ... Daniel L. Gillen, Pierre Baldi, David A. Bennett, Aron S. Buchman ...The retrosplenial cortex (RSC) is known to play a role in the retrieval of context memory, but its involvement in memory formation and consolidation is unclear. To better characterize the role of the RSC, we tested its involvement in the formation and ...Jarome TJ, Kwapis JL, Werner CT, Parsons RG, Gafford GM, Helmstetter FJ (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learn Mem 19: 300–306. [PMC free article] [Google Scholar] Jarome TJ, Werner CT, Kwapis JL, Helmstetter FJ (2011).Bellfy L, Kwapis JL. Molecular Mechanisms of Reconsolidation-Dependent Memory Updating. International Journal of Molecular Sciences. 21. PMID 32916796 DOI: 10.3390/ijms21186580 : 0.88: 2020: Wright DS, Bodinayake KK, Kwapis JL. Investigating Memory Updating in Mice Using the Objects in Updated Locations Task. Current Protocols in Neuroscience ...Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association.International Journal of Molecular Sciences Editorial Special Issue "Molecular Mechanisms of Memory Formation and Modification" Timothy J. Jarome 1,2,* and Janine L. Kwapis 3,4,* Citation: Jarome, T.J.; Kwapis, J.L. Special Issue "Molecular MechanismsJanine L Kwapis 1 , Timothy J Jarome 1 , Fred J Helmstetter 2 Affiliations 1 Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA. 2 Department of Psychology, University of PMID: 25512576 PMCID: 10. ...Emily M. Stuart, Destiny S. Wright, Chen-Yu Lo, Shoko Murakami, Hannah M. Boyd, Megan J. von Abo & Janine L. Kwapis Huck Institutes of the Life Sciences, The Pennsylvania State University ...Hannah M. Boyd1, Megan J. von Abo1, Istvan Albert2,3, Janine L. Kwapis1,* 1 Department of Biology, Pennsylvania State University, University Park, PA 16802, USA 2 Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA 3 Department of Biochemistry and Molecular Biology,Christopher W. Butler, 1 Ashley A. Keiser, 1 Janine L. Kwapis, 2 Nicole C. Berchtold, 1 Vanessa L. Wall, 1 Marcelo A. Wood, 1 and Carl W. Cotman 1 Christopher W. Butler 1 Department of Neurobiology and Behavior, University of California Irvine, Irvine, California 92617, USAEurope PMC is an archive of life sciences journal literature.Janine L. Kwapis, Timothy J. Jarome, and Fred J. Helmstetter Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA The extinction of delay fear conditioning relies on a neural circuit that has received much attention and is relatively well defined.Janine L. Kwapis, Ph.D., Department of Biology, Penn State University Public Neuroscience Seminar; Wednesday, December 4th, 2019; 11:00 am – 12:00pm; Fralin Auditorium; Aging is accompanied by impairments in both long-term memory and circadian rhythmicity.Nicole C Ferrara 1 2 , Janine L Kwapis 3 , Sydney Trask 4 5 Affiliations 1 Discipline of Physiology and Biophysics, Rosalind Franklin University, North Chicago, IL, United States. 2 Center for Neurobiology of Stress Resilience and …learning and memory processes (Kwapis et al., 2017; Malvaez et al., 2013; McQuown et al., 2011; Rogge, Singh, Dang,&Wood, 2013). Our laboratory has shown that HDAC3 plays a critical role in object location and fear related memory formation (Kwapis et alEpigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone …Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. by Janine L Kwapis, Yasaman Alaghband, Enikö A Kramár, Alberto J López, Annie Vogel Ciernia, André O White, Guanhua Shu, Diane Rhee, Christina M Michael, Emilie Montellier, Yu Liu, Christophe N Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P Matheos, Marcelo A Wood.Alzheimer's Disease affects 5.4 million Americans [1] and by 2030, approximately 13.8 million people 65 or older are projected to have the disease [2]. Even more individuals will experience normal age...Chad W. Smies a, Janine L. Kwapis a, ∗ a Department of Biology, Pennsylvania State University, University Park, PA b Department ofNeurobiology and Behavior, University California, Irvine, CA a r t i c l e i n f o Article Aginghistory: both Received 17 October 2022 Revised 3 February 2023 Accepted 18 February 2023 Available online 23 February ...Timothy J Jarome 1 , Craig T Werner, Janine L Kwapis, Fred J Helmstetter. Affiliation 1 Department of Psychology, University of Wisconsin, Milwaukee, Wisconsin, United States of America. PMID: 21961035 PMCID: PMC3178530 DOI: 10.1371/journal.pone .... What time does the dollar tree open near me